Assay Detail
Binding
CHEMBL754770
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition rat liver microsome cytochrome P450DM
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Lanosterol 14-alpha demethylase (CHEMBL4981) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
32-Methyl-32-oxylanosterols: dual-action inhibitors of cholesterol biosynthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.20 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133834 | — | — | 2 | 6.52 |
| CHEMBL133434 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133834 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL133834 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL133434 | — | IC50 | = | 2700.0 | nM | 5.57 |