Assay Detail
Binding
CHEMBL754814
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In vitro inhibition concentration was evaluated on the effect of conversion by Nitric Oxide synthase of [3H]L-arginine into [3H]L-citrulline
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel lipoic acid analogues that inhibit nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.68 | 5.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32644 | — | — | 1 | 5.98 |
| CHEMBL33692 | — | — | 1 | 5.94 |
| CHEMBL33601 | — | — | 1 | 5.64 |
| CHEMBL32450 | — | — | 1 | 5.46 |
| CHEMBL34792 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32644 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL33692 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL33601 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL32450 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL34792 | — | IC50 | = | 4400.0 | nM | 5.36 |