Assay Detail
Binding
CHEMBL754826
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Opioid receptor kappa 1 using [3H]diprenorphine as radioligand in guinea pig cerebellar membrane in presence of 120 mM NaCl + 50 uM Gpp(NH)p
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Cerebellum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.17 | 7.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384584 | — | — | 1 | 7.78 |
| CHEMBL442323 | — | — | 1 | 7.57 |
| CHEMBL406893 | — | — | 1 | 7.54 |
| CHEMBL266782 | — | — | 1 | 7.19 |
| CHEMBL268818 | — | — | 1 | 7.03 |
| CHEMBL406338 | — | — | 1 | 6.64 |
| CHEMBL267215 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384584 | — | IC50 | = | 16.5 | nM | 7.78 |
| CHEMBL442323 | — | IC50 | = | 27.1 | nM | 7.57 |
| CHEMBL406893 | — | IC50 | = | 29.1 | nM | 7.54 |
| CHEMBL266782 | — | IC50 | = | 64.6 | nM | 7.19 |
| CHEMBL268818 | — | IC50 | = | 93.7 | nM | 7.03 |
| CHEMBL406338 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL267215 | — | IC50 | = | 391.0 | nM | 6.41 |