Assay Detail
Binding
CHEMBL754944
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Binding assay evaluated using DPPE radioligand in CHO cells transfected with mouse Opioid receptor delta 1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of isothiocyanate-containing derivatives of the delta-opioid receptor antagonist Tyr-Tic-Phe-Phe (TIPP) as potential affinity labels for delta-opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.88 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL149788 | — | — | 1 | 8.27 |
| CHEMBL191751 | — | — | 1 | 8.24 |
| CHEMBL2370603 | — | — | 1 | 7.93 |
| CHEMBL146183 | — | — | 1 | 7.91 |
| CHEMBL2370606 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL149788 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL191751 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL2370603 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL146183 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL2370606 | — | IC50 | = | 87.7 | nM | 7.06 |