Assay Detail
Functional
CHEMBL754952
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antimalarial activity of sixteen dispiro-1,2,4, 5-tetraoxanes: alkyl-substituted 7,8,15,16-tetraoxadispiro[5.2.5. 2]hexadecanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.57 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301267 | ARTEMOTIL | 2.0 | 1 | 8.85 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.14 |
| CHEMBL319599 | — | — | 1 | 8.00 |
| CHEMBL96830 | — | — | 1 | 7.82 |
| CHEMBL93458 | — | — | 1 | 7.72 |
| CHEMBL92197 | — | — | 1 | 7.72 |
| CHEMBL93291 | — | — | 1 | 7.68 |
| CHEMBL278291 | WR-148999 | — | 1 | 7.50 |
| CHEMBL92920 | — | — | 1 | 7.43 |
| CHEMBL315158 | — | — | 1 | 7.41 |
| CHEMBL91761 | — | — | 1 | 7.37 |
| CHEMBL433368 | — | — | 1 | 7.31 |
| CHEMBL92507 | — | — | 1 | 7.29 |
| CHEMBL91857 | — | — | 1 | 7.03 |
| CHEMBL93301 | — | — | 1 | 7.00 |
| CHEMBL328771 | — | — | 1 | 6.80 |
| CHEMBL442960 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301267 | ARTEMOTIL | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL319599 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL96830 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL93458 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL92197 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL93291 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL278291 | WR-148999 | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL92920 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL315158 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL91761 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL433368 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL92507 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL91857 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL93301 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL328771 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL442960 | — | IC50 | > | 1000.0 | nM | - |