Assay Detail
Binding
CHEMBL754962
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Inhibition of [3H]DAGO binding to trat brain opioid receptor mu in P2 membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Function of negative charge in the "address domain" of deltorphins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.07 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282943 | — | — | 1 | 6.75 |
| CHEMBL317956 | DELTORPHIN C | — | 1 | 6.41 |
| CHEMBL296603 | DELTORPHINE II | — | 1 | 5.89 |
| CHEMBL26575 | DELTORPHIN | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282943 | — | Ki | = | 175.6 | nM | 6.75 |
| CHEMBL317956 | DELTORPHIN C | Ki | = | 387.3 | nM | 6.41 |
| CHEMBL296603 | DELTORPHINE II | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL26575 | DELTORPHIN | Ki | = | 5849.0 | nM | 5.23 |