Assay Detail
Binding
CHEMBL754968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]DAMGO to opioid receptor mu of rat fore brain membranes was determined
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Effect of modification of the basic residues of dynorphin A-(1-13) amide on kappa opioid receptor selectivity and opioid activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 10.19 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438741 | — | — | 1 | 10.74 |
| CHEMBL440446 | — | — | 1 | 10.52 |
| CHEMBL440987 | — | — | 1 | 10.37 |
| CHEMBL415617 | — | — | 1 | 10.34 |
| CHEMBL266515 | — | — | 1 | 10.26 |
| CHEMBL263597 | — | — | 1 | 10.21 |
| CHEMBL266717 | — | — | 1 | 10.12 |
| CHEMBL263583 | — | — | 1 | 9.74 |
| CHEMBL415330 | — | — | 1 | 9.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438741 | — | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL440446 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL440987 | — | Ki | = | 0.043 | nM | 10.37 |
| CHEMBL415617 | — | Ki | = | 0.046 | nM | 10.34 |
| CHEMBL266515 | — | Ki | = | 0.055 | nM | 10.26 |
| CHEMBL263597 | — | Ki | = | 0.061 | nM | 10.21 |
| CHEMBL266717 | — | Ki | = | 0.075 | nM | 10.12 |
| CHEMBL263583 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL415330 | — | Ki | = | 0.4 | nM | 9.40 |