Assay Detail
Binding
CHEMBL754981
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Oxidosqualene-lanosterol cyclase from human liver microsomes
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Liver |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.31 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67133 | — | — | 1 | 8.54 |
| CHEMBL63524 | — | — | 1 | 8.52 |
| CHEMBL65024 | — | — | 1 | 8.46 |
| CHEMBL66638 | — | — | 1 | 8.39 |
| CHEMBL416694 | — | — | 1 | 8.27 |
| CHEMBL304858 | — | — | 1 | 8.19 |
| CHEMBL66412 | — | — | 1 | 7.95 |
| CHEMBL65296 | — | — | 1 | 7.87 |
| CHEMBL65230 | — | — | 1 | 7.80 |
| CHEMBL62855 | — | — | 1 | 7.72 |
| CHEMBL66424 | — | — | 1 | 7.71 |
| CHEMBL63522 | — | — | 1 | 7.66 |
| CHEMBL65730 | — | — | 1 | 7.54 |
| CHEMBL65601 | — | — | 1 | 7.54 |
| CHEMBL417571 | — | — | 1 | 7.44 |
| CHEMBL66202 | — | — | 1 | 7.41 |
| CHEMBL262532 | — | — | 1 | 7.32 |
| CHEMBL66359 | — | — | 1 | 7.15 |
| CHEMBL292514 | — | — | 1 | 7.01 |
| CHEMBL293005 | — | — | 1 | 6.65 |
| CHEMBL305157 | — | — | 1 | 6.62 |
| CHEMBL305328 | — | — | 1 | 6.42 |
| CHEMBL292084 | — | — | 1 | 6.36 |
| CHEMBL65553 | — | — | 1 | 6.30 |
| CHEMBL445353 | — | — | 1 | 6.21 |
| CHEMBL291640 | — | — | 1 | 6.19 |
| CHEMBL63630 | — | — | 1 | 5.73 |
| CHEMBL294809 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67133 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL63524 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL65024 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL66638 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL416694 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL304858 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL66412 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL65296 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL65230 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL62855 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL66424 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL63522 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL65730 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL65601 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL417571 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL66202 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL262532 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL66359 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL292514 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL293005 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL305157 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL305328 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL292084 | — | IC50 | = | 439.0 | nM | 6.36 |
| CHEMBL65553 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL445353 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL291640 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL63630 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL294809 | — | IC50 | = | 1900.0 | nM | 5.72 |