Assay Detail
Binding
CHEMBL754999
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity against Opioid receptor kappa 1 was determined by measuring the inhibition of [3H]U-69593 binding to guinea pig cerebellar membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.38 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384584 | — | — | 1 | 8.77 |
| CHEMBL406893 | — | — | 1 | 8.58 |
| CHEMBL268818 | — | — | 1 | 8.49 |
| CHEMBL266782 | — | — | 1 | 7.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384584 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL406893 | — | Ki | = | 2.61 | nM | 8.58 |
| CHEMBL268818 | — | Ki | = | 3.24 | nM | 8.49 |
| CHEMBL266782 | — | Ki | = | 21.3 | nM | 7.67 |