Assay Detail
Binding
CHEMBL755002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity of compound towards Opioid receptor kappa 1 was determined in presence of [3H]bremazocine radioligand
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.06 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL607449 | — | — | 1 | 6.28 |
| CHEMBL607331 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL607449 | — | Ki | = | 523.0 | nM | 6.28 |
| CHEMBL607331 | — | Ki | = | 1444.0 | nM | 5.84 |