Assay Detail
Binding
CHEMBL755009
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In vitro binding activity against opioid receptor mu using [3H]DAGO) as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.16 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169366 | — | — | 1 | 8.27 |
| CHEMBL168723 | — | — | 1 | 7.99 |
| CHEMBL634 | ALFENTANIL | 4.0 | 1 | 7.82 |
| CHEMBL424400 | — | — | 1 | 5.92 |
| CHEMBL169587 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169366 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL168723 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL634 | ALFENTANIL | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL424400 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL169587 | — | IC50 | = | 1600.0 | nM | 5.80 |