Assay Detail
Binding
CHEMBL755107
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Inhibition of neutral endopeptidase (NEP)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.03 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287358 | — | — | 1 | 8.40 |
| CHEMBL43370 | — | — | 1 | 7.05 |
| CHEMBL146936 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287358 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL43370 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL146936 | — | IC50 | = | 2300.0 | nM | 5.64 |