Assay Detail

CHEMBL755108

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Binding

Inhibitory activity against rabbit kidney neutral endopeptidase (NEP)

ChEMBL ↗

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Target

Neprilysin (CHEMBL3768) ↗

Open DB target context

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Primary target Neprilysin

CHEMBL3768

Anchored from Assay target.

Protein identity Neprilysin

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Oryctolagus cuniculus
Confidence	9 — Direct single protein target
Curated By	Intermediate

Target

Neprilysin (CHEMBL3768) ↗

Type	SINGLE PROTEIN
Organism	Oryctolagus cuniculus

Publication

Kelatorphan and related analogs: potent and selective inhibitors of leukotriene A4 hydrolase

Penning TD, Askonas LJ, Djuric SW, Haack RA, Yu SS, Michener ML, Krivi GG, Pyla E
Bioorg Med Chem Lett (1995) 5 : 2517 -2522
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.34	7.34

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL85320	KELATORPHAN	—	1	7.34
CHEMBL85512	—	—	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL85320	KELATORPHAN	IC50	=	46.0	nM	7.34
CHEMBL85512	—	IC50	>	36000.0	nM	-