Assay Detail
Binding
CHEMBL755110
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Inhibitory activity was tested against neutral endopeptidase
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.81 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51625 | — | — | 1 | 8.89 |
| CHEMBL20341 | — | — | 1 | 8.85 |
| CHEMBL19494 | — | — | 1 | 8.66 |
| CHEMBL20123 | — | — | 1 | 8.64 |
| CHEMBL21025 | — | — | 1 | 8.55 |
| CHEMBL277238 | — | — | 1 | 8.54 |
| CHEMBL19755 | — | — | 1 | 8.52 |
| CHEMBL19165 | — | — | 1 | 8.46 |
| CHEMBL20067 | — | — | 1 | 8.44 |
| CHEMBL287896 | — | — | 1 | 8.42 |
| CHEMBL19846 | — | — | 1 | 8.40 |
| CHEMBL20419 | — | — | 1 | 8.39 |
| CHEMBL19070 | — | — | 1 | 8.35 |
| CHEMBL19951 | — | — | 1 | 8.28 |
| CHEMBL1794012 | — | — | 1 | 8.28 |
| CHEMBL1794004 | — | — | 1 | 8.26 |
| CHEMBL282469 | — | — | 1 | 8.02 |
| CHEMBL279966 | — | — | 1 | 8.00 |
| CHEMBL20193 | — | — | 1 | 7.85 |
| CHEMBL19816 | — | — | 1 | 7.70 |
| CHEMBL410980 | — | — | 1 | 7.70 |
| CHEMBL19820 | — | — | 1 | 7.66 |
| CHEMBL19621 | — | — | 1 | 7.64 |
| CHEMBL19936 | — | — | 1 | 7.62 |
| CHEMBL19647 | — | — | 1 | 7.62 |
| CHEMBL283741 | — | — | 1 | 7.52 |
| CHEMBL1794011 | — | — | 1 | 7.50 |
| CHEMBL20966 | — | — | 1 | 7.40 |
| CHEMBL277707 | — | — | 1 | 7.35 |
| CHEMBL19573 | — | — | 1 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51625 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL20341 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL19494 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL20123 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL21025 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL277238 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL19755 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL19165 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL20067 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL287896 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL19846 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL20419 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL19070 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL19951 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL1794012 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL1794004 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL282469 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL279966 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL20193 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL410980 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL19816 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL19820 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL19621 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL19936 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL19647 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL283741 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1794011 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL20966 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL277707 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL19573 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL282664 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL20053 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL418738 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL280203 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL20322 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL19935 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1794014 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL20574 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL283315 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL20182 | — | IC50 | = | 190.0 | nM | 6.72 |