Assay Detail
Binding
CHEMBL755112
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Tested for inhibitory potency against neutral endopeptidase (NEP)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
New thiol inhibitors of neutral endopeptidase EC 3.4.24.11: synthesis and enzyme active-site recognition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.80 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55286 | — | — | 1 | 8.44 |
| CHEMBL47289 | — | — | 1 | 7.75 |
| CHEMBL54601 | — | — | 1 | 7.36 |
| CHEMBL54942 | — | — | 1 | 6.89 |
| CHEMBL301703 | — | — | 1 | 6.82 |
| CHEMBL293794 | — | — | 1 | 6.72 |
| CHEMBL55583 | — | — | 1 | 6.66 |
| CHEMBL55103 | — | — | 1 | 6.66 |
| CHEMBL53141 | — | — | 1 | 6.60 |
| CHEMBL54823 | — | — | 1 | 6.58 |
| CHEMBL55721 | — | — | 1 | 6.57 |
| CHEMBL54477 | — | — | 1 | 6.54 |
| CHEMBL55520 | — | — | 1 | 6.50 |
| CHEMBL54457 | — | — | 1 | 6.50 |
| CHEMBL55613 | — | — | 1 | 6.46 |
| CHEMBL54796 | — | — | 1 | 6.46 |
| CHEMBL53621 | — | — | 1 | 6.44 |
| CHEMBL53678 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55286 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL47289 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL54601 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL54942 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL301703 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL293794 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL55583 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL55103 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL53141 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL54823 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL55721 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL54477 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL55520 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL54457 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL55613 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL54796 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL53621 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL53678 | — | IC50 | = | 380.0 | nM | 6.42 |