Assay Detail
Binding
CHEMBL755191
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Binding affinity of compound for Opioid receptor mu 1 was determined using [3H]DAMGO as radioligand from rat brain tissue
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Importance of phenolic address groups in opioid kappa receptor selective antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.10 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415247 | JDTIC | 1.0 | 1 | 8.43 |
| CHEMBL573214 | NORBINALTORPHIMINE | — | 2 | 8.08 |
| CHEMBL10986 | — | — | 1 | 6.77 |
| CHEMBL10872 | — | — | 1 | 6.11 |
| CHEMBL11285 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415247 | JDTIC | Ki | = | 3.73 | nM | 8.43 |
| CHEMBL573214 | NORBINALTORPHIMINE | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL573214 | NORBINALTORPHIMINE | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL10986 | — | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL10872 | — | Ki | = | 775.0 | nM | 6.11 |
| CHEMBL11285 | — | Ki | = | 946.0 | nM | 6.02 |