Assay Detail
Binding
CHEMBL755352
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Inhibition of [3H]- DAMGO binding to Rat brain Opioid receptor mu 1
13
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.28 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140050 | ETORPHINE | 2.0 | 1 | 9.85 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.71 |
| CHEMBL65348 | — | — | 2 | 7.62 |
| CHEMBL302454 | — | — | 2 | 7.54 |
| CHEMBL290301 | — | — | 1 | 7.53 |
| CHEMBL340032 | DADLE | — | 1 | 7.38 |
| CHEMBL440123 | — | — | 1 | 7.32 |
| CHEMBL2111530 | — | — | 1 | 7.18 |
| CHEMBL38791 | — | — | 1 | 6.86 |
| CHEMBL13470 | SNC-80 | — | 1 | 5.61 |
| CHEMBL303113 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140050 | ETORPHINE | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL70 | MORPHINE | IC50 | = | 1.94 | nM | 8.71 |
| CHEMBL65348 | — | IC50 | = | 24.2 | nM | 7.62 |
| CHEMBL302454 | — | IC50 | = | 28.8 | nM | 7.54 |
| CHEMBL302454 | — | IC50 | = | 29.4 | nM | 7.53 |
| CHEMBL290301 | — | IC50 | = | 29.8 | nM | 7.53 |
| CHEMBL340032 | DADLE | IC50 | = | 41.9 | nM | 7.38 |
| CHEMBL440123 | — | IC50 | = | 48.4 | nM | 7.32 |
| CHEMBL2111530 | — | IC50 | = | 66.4 | nM | 7.18 |
| CHEMBL38791 | — | IC50 | = | 136.8 | nM | 6.86 |
| CHEMBL65348 | — | IC50 | = | 474.2 | nM | 6.32 |
| CHEMBL13470 | SNC-80 | IC50 | = | 2467.0 | nM | 5.61 |
| CHEMBL303113 | — | IC50 | = | 7267.0 | nM | 5.14 |