Assay Detail
Binding
CHEMBL755420
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity against Opioid receptor kappa 1 was determined by measuring the inhibition of [3H]bremazocine binding to guinea pig cerebellar membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.81 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442323 | — | — | 1 | 10.70 |
| CHEMBL268818 | — | — | 1 | 10.54 |
| CHEMBL384584 | — | — | 1 | 10.52 |
| CHEMBL406338 | — | — | 1 | 10.31 |
| CHEMBL406893 | — | — | 1 | 9.72 |
| CHEMBL266782 | — | — | 1 | 8.44 |
| CHEMBL267215 | — | — | 1 | 8.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442323 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL268818 | — | Ki | = | 0.029 | nM | 10.54 |
| CHEMBL384584 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL406338 | — | Ki | = | 0.049 | nM | 10.31 |
| CHEMBL406893 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL266782 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL267215 | — | Ki | = | 3.66 | nM | 8.44 |