Assay Detail
Binding
CHEMBL755450
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Inhibition of [3H]BTX-B binding to Neuronal voltage-dependent sodium channel of rat cerebral cortex synaptoneurosomes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Sodium channel alpha subunits; brain (Types I, II, III) (CHEMBL2095171) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Effects of log P and phenyl ring conformation on the binding of 5-phenylhydantoins to the voltage-dependent sodium channel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.27 | 4.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL288505 | — | — | 1 | 4.41 |
| CHEMBL16 | PHENYTOIN | 4.0 | 1 | 4.40 |
| CHEMBL39889 | — | — | 1 | 4.24 |
| CHEMBL39247 | — | — | 1 | 4.02 |
| CHEMBL39010 | — | — | 1 | - |
| CHEMBL39377 | — | — | 1 | - |
| CHEMBL289431 | — | — | 1 | - |
| CHEMBL290090 | — | — | 1 | - |
| CHEMBL288861 | — | — | 1 | - |
| CHEMBL38760 | — | — | 1 | - |
| CHEMBL289046 | — | — | 1 | - |
| CHEMBL38588 | — | — | 1 | - |
| CHEMBL290743 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL288505 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL16 | PHENYTOIN | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL39889 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL39247 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL39010 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL39377 | — | IC50 | = | 251000.0 | nM | - |
| CHEMBL289431 | — | IC50 | = | 2112000.0 | nM | - |
| CHEMBL290090 | — | IC50 | = | 251000.0 | nM | - |
| CHEMBL288861 | — | IC50 | = | 162000.0 | nM | - |
| CHEMBL38760 | — | IC50 | = | 225000.0 | nM | - |
| CHEMBL289046 | — | IC50 | = | 851000.0 | nM | - |
| CHEMBL38588 | — | IC50 | = | 720000.0 | nM | - |
| CHEMBL290743 | — | IC50 | = | 250000.0 | nM | - |