Assay Detail
Binding
CHEMBL755495
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In vitro binding affinity against Opioid receptor kappa 1 in rat brain homogenates.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3-Alkyl ethers of clocinnamox: delayed long-term mu-antagonists with variable mu efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.62 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386492 | CLOCINNAMOX | — | 1 | 8.27 |
| CHEMBL610543 | — | — | 1 | 7.83 |
| CHEMBL610544 | — | — | 1 | 7.75 |
| CHEMBL610030 | — | — | 1 | 7.75 |
| CHEMBL610546 | — | — | 1 | 7.72 |
| CHEMBL610028 | — | — | 1 | 7.72 |
| CHEMBL610286 | — | — | 1 | 7.02 |
| CHEMBL610287 | — | — | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386492 | CLOCINNAMOX | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL610543 | — | Ki | = | 14.9 | nM | 7.83 |
| CHEMBL610544 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL610030 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL610546 | — | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL610028 | — | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL610286 | — | Ki | = | 95.4 | nM | 7.02 |
| CHEMBL610287 | — | Ki | = | 131.2 | nM | 6.88 |