Assay Detail
Functional
CHEMBL755504
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Effective concentration for half-maximal stimulation was determined by [35S]GTP-gamma-S, assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of dynorphin a analogues modified in the address sequence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.66 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216640 | — | — | 1 | 9.13 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | 8.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216640 | — | EC50 | = | 0.74 | nM | 9.13 |
| CHEMBL80 | NALOXONE | EC50 | = | 6.6 | nM | 8.18 |