Assay Detail
Binding
CHEMBL755533
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Binding affinity against NEP from rabbit kidney(neutral endopeptidase)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.35 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348205 | — | — | 1 | 8.40 |
| CHEMBL356858 | — | — | 1 | 8.27 |
| CHEMBL148777 | — | — | 1 | 7.77 |
| CHEMBL358903 | — | — | 1 | 7.66 |
| CHEMBL147285 | — | — | 1 | 7.47 |
| CHEMBL146746 | — | — | 1 | 6.66 |
| CHEMBL347763 | — | — | 1 | 6.28 |
| CHEMBL151631 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348205 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL356858 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL148777 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL358903 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL147285 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL146746 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL347763 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL151631 | — | Ki | = | 520.0 | nM | 6.28 |