Assay Detail
Binding
CHEMBL755534
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In vitro inhibition of Neutral endopeptidase.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
N-[2-(Indan-1-yl)-3-mercapto-propionyl] amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE, ECE): In vitro and In vivo activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 8.17 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285490 | — | — | 1 | 9.15 |
| CHEMBL60439 | — | — | 1 | 8.89 |
| CHEMBL35643 | — | — | 1 | 8.74 |
| CHEMBL301646 | — | — | 1 | 8.74 |
| CHEMBL304629 | — | — | 1 | 8.57 |
| CHEMBL61713 | — | — | 1 | 8.42 |
| CHEMBL262267 | — | — | 1 | 8.40 |
| CHEMBL302837 | — | — | 1 | 8.30 |
| CHEMBL305089 | — | — | 1 | 8.30 |
| CHEMBL61016 | — | — | 1 | 8.22 |
| CHEMBL304218 | — | — | 1 | 8.10 |
| CHEMBL304209 | — | — | 1 | 8.03 |
| CHEMBL303302 | — | — | 1 | 7.96 |
| CHEMBL59674 | — | — | 1 | 7.96 |
| CHEMBL293685 | — | — | 1 | 7.89 |
| CHEMBL61640 | — | — | 1 | 7.85 |
| CHEMBL60363 | — | — | 1 | 7.82 |
| CHEMBL305388 | — | — | 1 | 7.82 |
| CHEMBL59856 | — | — | 1 | 7.80 |
| CHEMBL59762 | — | — | 1 | 7.52 |
| CHEMBL292534 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285490 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL60439 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL35643 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL301646 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL304629 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL61713 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL262267 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL302837 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL305089 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL61016 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL304218 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL304209 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL303302 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL59674 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL293685 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL61640 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL60363 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL305388 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL59856 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL59762 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL292534 | — | Ki | = | 78.0 | nM | 7.11 |