Assay Detail
Binding
CHEMBL755535
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Inhibition of neutral endopeptidase (NEP)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.97 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285619 | — | — | 1 | 8.66 |
| CHEMBL10247 | THIORPHAN | -1.0 | 1 | 8.40 |
| CHEMBL37596 | — | — | 1 | 6.85 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285619 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL10247 | THIORPHAN | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL37596 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL1560 | CAPTOPRIL | Ki | > | 1000.0 | nM | - |