Assay Detail
Binding
CHEMBL755536
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Inhibition of neutral endopeptidase (NEP) isolated from rabbit kidney
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.15 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285490 | — | — | 1 | 9.15 |
| CHEMBL37841 | — | — | 1 | 8.82 |
| CHEMBL35643 | — | — | 1 | 8.74 |
| CHEMBL285447 | — | — | 1 | 8.68 |
| CHEMBL38075 | — | — | 1 | 8.66 |
| CHEMBL285204 | — | — | 1 | 8.62 |
| CHEMBL38249 | — | — | 1 | 8.60 |
| CHEMBL35749 | — | — | 1 | 8.52 |
| CHEMBL288584 | — | — | 1 | 8.52 |
| CHEMBL290610 | — | — | 1 | 8.52 |
| CHEMBL290492 | — | — | 1 | 8.35 |
| CHEMBL285960 | — | — | 1 | 8.32 |
| CHEMBL289518 | — | — | 1 | 8.30 |
| CHEMBL288814 | — | — | 1 | 8.30 |
| CHEMBL38235 | — | — | 1 | 8.27 |
| CHEMBL37276 | — | — | 1 | 8.10 |
| CHEMBL2115345 | — | — | 1 | 8.00 |
| CHEMBL287261 | — | — | 1 | 7.66 |
| CHEMBL2114403 | — | — | 1 | 7.57 |
| CHEMBL288911 | — | — | 1 | 7.52 |
| CHEMBL37711 | — | — | 1 | 7.46 |
| CHEMBL288302 | — | — | 1 | 7.46 |
| CHEMBL287801 | — | — | 1 | 7.37 |
| CHEMBL289223 | — | — | 1 | 7.29 |
| CHEMBL34876 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285490 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL37841 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL35643 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL285447 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL38075 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL285204 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL38249 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL35749 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL288584 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL290610 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL290492 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL285960 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL289518 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL288814 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL38235 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL37276 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL2115345 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL287261 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL2114403 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL288911 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL37711 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL288302 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL287801 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL289223 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL34876 | — | Ki | = | 135.0 | nM | 6.87 |