Assay Detail
Binding
CHEMBL755537
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Tested for binding affinity against neutral endopeptidase (NEP)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
New thiol inhibitors of neutral endopeptidase EC 3.4.24.11: synthesis and enzyme active-site recognition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 8.34 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10247 | THIORPHAN | -1.0 | 1 | 8.72 |
| CHEMBL113759 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10247 | THIORPHAN | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL113759 | — | Ki | = | 11.0 | nM | 7.96 |