Assay Detail
Binding
CHEMBL755540
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of neutral endopeptidase purified from rat kidney using fluorimetry assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.66 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL41753 | — | — | 1 | 8.40 |
| CHEMBL289556 | OMAPATRILAT | 2.0 | 1 | 8.10 |
| CHEMBL290754 | — | — | 1 | 8.05 |
| CHEMBL41201 | — | — | 1 | 7.75 |
| CHEMBL39775 | — | — | 1 | 7.60 |
| CHEMBL289534 | — | — | 1 | 7.58 |
| CHEMBL39774 | — | — | 1 | 7.38 |
| CHEMBL287896 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL41753 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL289556 | OMAPATRILAT | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL290754 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL41201 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL39775 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL289534 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL39774 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL287896 | — | IC50 | = | 400.0 | nM | 6.40 |