Assay Detail
Binding
CHEMBL755542
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for inhibition of rat kidney neutral endopeptidase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of a new class of conformationally constrained inhibitors to probe the active sites of thermolysine and neutral endopeptidase 24.11
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.55 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61512 | (R)-THIORPHAN | — | 1 | 8.80 |
| CHEMBL298827 | (S)-THIORPHAN | — | 1 | 8.72 |
| CHEMBL63704 | — | — | 1 | 6.37 |
| CHEMBL67069 | — | — | 1 | 6.32 |
| CHEMBL64847 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61512 | (R)-THIORPHAN | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL298827 | (S)-THIORPHAN | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL63704 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL67069 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL64847 | — | IC50 | > | 300.0 | nM | - |