Assay Detail
Binding
CHEMBL755560
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Binding affinity against opioid receptor mu in rats by displacing [3H]-DAGO
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Para-substituted Phe3 deltorphin analogues: enhanced selectivity of halogenated derivatives for delta opioid receptor sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.01 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317956 | DELTORPHIN C | — | 1 | 6.57 |
| CHEMBL342209 | — | — | 1 | 6.54 |
| CHEMBL140384 | — | — | 1 | 6.30 |
| CHEMBL263670 | — | — | 1 | 6.26 |
| CHEMBL296603 | DELTORPHINE II | — | 1 | 6.20 |
| CHEMBL142547 | — | — | 1 | 5.85 |
| CHEMBL143354 | — | — | 1 | 5.84 |
| CHEMBL143208 | — | — | 1 | 5.62 |
| CHEMBL140845 | — | — | 1 | 5.61 |
| CHEMBL139885 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317956 | DELTORPHIN C | Ki | = | 272.0 | nM | 6.57 |
| CHEMBL342209 | — | Ki | = | 287.0 | nM | 6.54 |
| CHEMBL140384 | — | Ki | = | 506.0 | nM | 6.30 |
| CHEMBL263670 | — | Ki | = | 554.0 | nM | 6.26 |
| CHEMBL296603 | DELTORPHINE II | Ki | = | 638.0 | nM | 6.20 |
| CHEMBL142547 | — | Ki | = | 1413.0 | nM | 5.85 |
| CHEMBL143354 | — | Ki | = | 1429.0 | nM | 5.84 |
| CHEMBL143208 | — | Ki | = | 2391.0 | nM | 5.62 |
| CHEMBL140845 | — | Ki | = | 2460.0 | nM | 5.61 |
| CHEMBL139885 | — | Ki | = | 4787.0 | nM | 5.32 |