Assay Detail
Functional
CHEMBL755736
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Inhibitory concentration to reduce cell number to 50% of Murine P388 leukemia cell culture
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor properties of N-[2-(dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: a new class of putative topoisomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.55 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.82 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 7.70 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 7.60 |
| CHEMBL64927 | — | — | 1 | 7.60 |
| CHEMBL303785 | — | — | 1 | 7.34 |
| CHEMBL9940 | — | — | 1 | 7.15 |
| CHEMBL65436 | — | — | 1 | 7.07 |
| CHEMBL293859 | — | — | 1 | 7.06 |
| CHEMBL62347 | — | — | 1 | 7.00 |
| CHEMBL64036 | — | — | 1 | 6.89 |
| CHEMBL60437 | — | — | 1 | 6.77 |
| CHEMBL63120 | — | — | 1 | 6.44 |
| CHEMBL62522 | — | — | 1 | 6.43 |
| CHEMBL62763 | — | — | 1 | 6.17 |
| CHEMBL62789 | — | — | 1 | 6.16 |
| CHEMBL60552 | — | — | 1 | 5.80 |
| CHEMBL418668 | — | — | 1 | 5.75 |
| CHEMBL62883 | — | — | 1 | 5.66 |
| CHEMBL64307 | — | — | 1 | 5.24 |
| CHEMBL291885 | — | — | 1 | 5.17 |
| CHEMBL64382 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL43 | AMSACRINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL64927 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL303785 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL9940 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL65436 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL293859 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL62347 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL64036 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL60437 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL63120 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL62522 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL62763 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL62789 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL60552 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL418668 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL62883 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL64307 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL291885 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL64382 | — | IC50 | = | 15000.0 | nM | 4.82 |