Assay Detail
Functional
CHEMBL755789
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic activity in guinea pig ileal longitudinal muscle
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Muscle tissue |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Opioid receptor (mu and kappa) (CHEMBL2111465) ↗| Type | SELECTIVITY GROUP |
| Organism | Cavia porcellus |
Publication
Binaltorphimine-related bivalent ligands and their kappa opioid receptor antagonist selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.79 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL607010 | — | — | 1 | 7.28 |
| CHEMBL606959 | — | — | 1 | 6.60 |
| CHEMBL606960 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL607010 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL606959 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL606960 | — | IC50 | = | 330.0 | nM | 6.48 |