Assay Detail
Binding
CHEMBL755869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]U-69593 from Opioid receptor kappa 1 of guinea pig brain membranes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
8-Carboxamidocyclazocine analogues: redefining the structure-activity relationships of 2,6-methano-3-benzazocines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 8.24 | 10.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | 2.0 | 1 | 10.28 |
| CHEMBL3085528 | — | — | 1 | 9.74 |
| CHEMBL2368218 | — | — | 1 | 9.55 |
| CHEMBL58646 | — | — | 1 | 9.28 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | — | 1 | 9.21 |
| CHEMBL60869 | — | — | 1 | 9.15 |
| CHEMBL160924 | — | — | 1 | 8.70 |
| CHEMBL157301 | — | — | 1 | 8.59 |
| CHEMBL160677 | — | — | 1 | 7.51 |
| CHEMBL157313 | — | — | 1 | 7.17 |
| CHEMBL154255 | — | — | 1 | 7.15 |
| CHEMBL2021605 | — | — | 1 | 7.12 |
| CHEMBL293103 | — | — | 1 | 6.34 |
| CHEMBL346813 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56585 | CYCLAZOCINE | Ki | = | 0.052 | nM | 10.28 |
| CHEMBL3085528 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL2368218 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL58646 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL60869 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL160924 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL157301 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL160677 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL157313 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL154255 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL2021605 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL293103 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL346813 | — | Ki | = | 2500.0 | nM | 5.60 |