Assay Detail
Binding
CHEMBL755871
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes, at highest concentration of 7000 nM tested
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.14 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150609 | — | — | 1 | 5.70 |
| CHEMBL555571 | — | — | 1 | 5.00 |
| CHEMBL150430 | — | — | 1 | 5.00 |
| CHEMBL127240 | — | — | 1 | 5.00 |
| CHEMBL125626 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150609 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL555571 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL150430 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL127240 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL125626 | — | Ki | = | 10000.0 | nM | 5.00 |