Assay Detail
Binding
CHEMBL755915
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Compound was tested for the inhibition of norepinephrine [3H]NE reuptake into rat cortical membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of substituted 3,4-diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.72 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296907 | — | — | 1 | 7.58 |
| CHEMBL49736 | — | — | 1 | 7.44 |
| CHEMBL301094 | — | — | 1 | 7.07 |
| CHEMBL48892 | — | — | 1 | 7.00 |
| CHEMBL120901 | — | — | 1 | 6.97 |
| CHEMBL52392 | — | — | 1 | 6.85 |
| CHEMBL297102 | — | — | 1 | 6.85 |
| CHEMBL51993 | — | — | 1 | 6.10 |
| CHEMBL50901 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296907 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL49736 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL301094 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL48892 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL120901 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL52392 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL297102 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL51993 | — | Ki | = | 801.0 | nM | 6.10 |
| CHEMBL50901 | — | Ki | = | 22100.0 | nM | 4.66 |