Assay Detail
Binding
CHEMBL755960
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Binding affinity for the Opioid receptor mu 1
33
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.23 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | — | 1 | 8.77 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.74 |
| CHEMBL558979 | — | — | 1 | 7.58 |
| CHEMBL440765 | U-69593 | — | 1 | 7.28 |
| CHEMBL536937 | — | — | 1 | 7.09 |
| CHEMBL557426 | — | — | 1 | 6.85 |
| CHEMBL537165 | — | — | 1 | 6.72 |
| CHEMBL539582 | — | — | 1 | 6.68 |
| CHEMBL536939 | — | — | 1 | 6.46 |
| CHEMBL544960 | — | — | 2 | 6.39 |
| CHEMBL556957 | — | — | 1 | 6.34 |
| CHEMBL541619 | — | — | 1 | 6.21 |
| CHEMBL535801 | — | — | 1 | 6.14 |
| CHEMBL537169 | — | — | 1 | 6.09 |
| CHEMBL538309 | — | — | 1 | 6.06 |
| CHEMBL290543 | — | — | 1 | 6.06 |
| CHEMBL558608 | — | — | 2 | 5.85 |
| CHEMBL534684 | — | — | 1 | 5.70 |
| CHEMBL538308 | — | — | 1 | 5.62 |
| CHEMBL354548 | — | — | 1 | 5.54 |
| CHEMBL537616 | — | — | 1 | 5.48 |
| CHEMBL559217 | — | — | 1 | 5.46 |
| CHEMBL535581 | — | — | 1 | 5.44 |
| CHEMBL556547 | — | — | 1 | 5.40 |
| CHEMBL118865 | SPIRADOLINE | 2.0 | 1 | 5.19 |
| CHEMBL537615 | — | — | 1 | 5.10 |
| CHEMBL535133 | — | — | 1 | 4.75 |
| CHEMBL535803 | — | — | 1 | - |
| CHEMBL559214 | — | — | 1 | - |
| CHEMBL535130 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279968 | ETHYLKETOCYCLAZOCINE | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL70 | MORPHINE | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL558979 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL440765 | U-69593 | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL536937 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL557426 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL537165 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL539582 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL536939 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL544960 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL556957 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL541619 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL535801 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL537169 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL538309 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL290543 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL544960 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL558608 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL558608 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL534684 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL538308 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL354548 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL537616 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL559217 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL535581 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL556547 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL118865 | SPIRADOLINE | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL537615 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL535133 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL559214 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL556802 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL535803 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL535130 | — | Ki | > | 1000.0 | nM | - |