Assay Detail
Binding
CHEMBL755961
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Binding affinity of Opioid receptor mu 1 by the displacement of mu-selective [3H]DAGO from brain membrane preparations.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Hybrid bivalent ligands with opiate and enkephalin pharmacophores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.99 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL607319 | — | — | 1 | 8.74 |
| CHEMBL607322 | — | — | 1 | 8.26 |
| CHEMBL607321 | — | — | 1 | 7.96 |
| CHEMBL607320 | — | — | 1 | 7.72 |
| CHEMBL60377 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL607319 | — | Ki | = | 1.81 | nM | 8.74 |
| CHEMBL607322 | — | Ki | = | 5.48 | nM | 8.26 |
| CHEMBL607321 | — | Ki | = | 11.1 | nM | 7.96 |
| CHEMBL607320 | — | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL60377 | — | Ki | = | 52.9 | nM | 7.28 |