Assay Detail
Functional
CHEMBL755976
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV activity against multidrug resistant HIV TM strain by inhibition of HIV p24 antigen expression in peripheral blood mononuclear cells(PBMC)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.03 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49002 | — | — | 1 | 7.47 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.37 |
| CHEMBL299578 | — | — | 1 | 7.37 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 6.64 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 6.32 |
| CHEMBL50945 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49002 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL299578 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL116 | AMPRENAVIR | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL50945 | — | IC50 | > | 1000.0 | nM | - |