Assay Detail
Binding
CHEMBL756066
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Binding affinity against Opioid receptor kappa 1 of Guinea pig brain homogenate using [3H]U-69593
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis using a Fmoc-based strategy and biological activities of some reduced peptide bond pseudopeptide analogues of dynorphin A1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 9.05 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2370494 | — | — | 1 | 9.80 |
| CHEMBL2370495 | — | — | 1 | 9.62 |
| CHEMBL2370496 | — | — | 1 | 9.44 |
| CHEMBL2311023 | — | — | 1 | 9.26 |
| CHEMBL216640 | — | — | 1 | 9.24 |
| CHEMBL2311025 | — | — | 1 | 9.21 |
| CHEMBL2370497 | — | — | 1 | 9.05 |
| CHEMBL2311024 | — | — | 1 | 8.10 |
| CHEMBL2311022 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2370494 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL2370495 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL2370496 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL2311023 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL216640 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL2311025 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL2370497 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL2311024 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2311022 | — | IC50 | = | 17.0 | nM | 7.77 |