Assay Detail
Binding
CHEMBL756073
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Binding affinity towards Opioid receptor kappa 1 in guinea pig brain using [3H]U-69593 as radioligand.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Highly kappa receptor-selective dynorphin A analogues with modifications in position 3 of dynorphin A(1-11)-NH2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.11 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268874 | — | — | 1 | 9.24 |
| CHEMBL415795 | — | — | 1 | 9.12 |
| CHEMBL262963 | — | — | 1 | 8.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268874 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL415795 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL262963 | — | IC50 | = | 1.1 | nM | 8.96 |