Assay Detail
Binding
CHEMBL756074
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Binding affinity towards Opioid receptor kappa 1 using [3H]- U-69,593 (1.5 nM) as radioligand in guinea pig brain membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis of novel analogues of the delta opioid ligand SNC-80 using REM resin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.38 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL611165 | — | — | 1 | 5.68 |
| CHEMBL13470 | SNC-80 | — | 1 | 5.39 |
| CHEMBL611161 | — | — | 1 | 5.07 |
| CHEMBL1169547 | — | — | 1 | - |
| CHEMBL2374437 | — | — | 1 | - |
| CHEMBL611160 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL611165 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL13470 | SNC-80 | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL611161 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL1169547 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2374437 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL611160 | — | IC50 | > | 10000.0 | nM | - |