Assay Detail
Binding
CHEMBL756077
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Inhibition of [3H]- U69,593 binding to Guinea pig Opioid receptor kappa 1
13
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.15 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140050 | ETORPHINE | 2.0 | 1 | 8.74 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.57 |
| CHEMBL2111530 | — | — | 1 | 5.93 |
| CHEMBL302454 | — | — | 2 | 5.75 |
| CHEMBL340032 | DADLE | — | 1 | 5.36 |
| CHEMBL38791 | — | — | 1 | 5.29 |
| CHEMBL303113 | — | — | 1 | - |
| CHEMBL65348 | — | — | 2 | - |
| CHEMBL290301 | — | — | 1 | - |
| CHEMBL13470 | SNC-80 | — | 1 | - |
| CHEMBL440123 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140050 | ETORPHINE | IC50 | = | 1.82 | nM | 8.74 |
| CHEMBL70 | MORPHINE | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL2111530 | — | IC50 | = | 1162.0 | nM | 5.93 |
| CHEMBL302454 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL302454 | — | IC50 | = | 3959.0 | nM | 5.40 |
| CHEMBL340032 | DADLE | IC50 | = | 4404.0 | nM | 5.36 |
| CHEMBL38791 | — | IC50 | = | 5071.0 | nM | 5.29 |
| CHEMBL303113 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL65348 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL290301 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL13470 | SNC-80 | IC50 | > | 1000.0 | nM | - |
| CHEMBL65348 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL440123 | — | IC50 | > | 1000.0 | nM | - |