Assay Detail
Functional
CHEMBL756134
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxic effect in human peripheral blood monocyte cells(PBMC)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
HIV-1 neutralization and tumor cell proliferation inhibition in vitro by simplified analogues of pyrido[4,3,2-mn]thiazolo[5,4-b]acridine marine alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.02 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43184 | AMINACRINE | 2.0 | 1 | 5.67 |
| CHEMBL554190 | QUINACRINE DIHYDROCHLORIDE | — | 1 | 5.67 |
| CHEMBL542907 | — | — | 1 | 4.68 |
| CHEMBL92751 | — | — | 1 | 4.05 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
| CHEMBL55400 | PROFLAVINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43184 | AMINACRINE | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL554190 | QUINACRINE DIHYDROCHLORIDE | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL542907 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL92751 | — | IC50 | = | 89600.0 | nM | 4.05 |
| CHEMBL129 | ZIDOVUDINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL55400 | PROFLAVINE | IC50 | > | 1000.0 | nM | - |