Assay Detail
Functional
CHEMBL756142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for the inhibition of p24 production in HIV-1 IIIB infected human peripheral blood mononuclear cells (PBMC)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Peptidomimetic HIV protease inhibitors: phosphate prodrugs with improved biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.77 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2304047 | — | — | 1 | 8.62 |
| CHEMBL2304003 | — | — | 1 | 8.36 |
| CHEMBL1790706 | — | — | 1 | 8.08 |
| CHEMBL2304048 | — | — | 1 | 8.08 |
| CHEMBL316245 | — | — | 1 | 8.02 |
| CHEMBL3350189 | — | — | 1 | 7.30 |
| CHEMBL85132 | — | — | 1 | 7.15 |
| CHEMBL313256 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2304047 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL2304003 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL1790706 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL2304048 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL316245 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL3350189 | — | IC50 | = | 50.2 | nM | 7.30 |
| CHEMBL85132 | — | IC50 | = | 70.4 | nM | 7.15 |
| CHEMBL313256 | — | IC50 | = | 300.0 | nM | 6.52 |