Assay Detail
Binding
CHEMBL756146
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Inhibitory activity against Oxidosqualene-lanosterol cyclase enzyme obtained from rat liver
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-(1-oxododecyl)-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol: a potent competitive inhibitor of 2,3-oxidosqualene cyclase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.64 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17168 | — | — | 1 | 6.96 |
| CHEMBL122299 | — | — | 1 | 6.68 |
| CHEMBL279569 | — | — | 1 | 6.26 |
| CHEMBL17470 | — | — | 1 | 5.70 |
| CHEMBL308982 | — | — | 1 | 5.05 |
| CHEMBL119316 | — | — | 1 | 4.52 |
| CHEMBL331432 | — | — | 1 | 4.30 |
| CHEMBL120689 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17168 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL122299 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL279569 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL17470 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL308982 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL119316 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL331432 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL120689 | — | IC50 | > | 100000.0 | nM | - |