Assay Detail
Binding
CHEMBL756245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the Opioid receptor kappa 1 affinity using guinea pig brain membranes.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2-(3,4-Dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)-1-substituted- ethyl]-acetamides: the use of conformational analysis in the development of a novel series of potent opioid kappa agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.88 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56653 | — | — | 1 | 8.20 |
| CHEMBL38576 | ICI-199,441 | — | 1 | 8.16 |
| CHEMBL56651 | — | — | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56653 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL38576 | ICI-199,441 | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL56651 | — | IC50 | = | 53.2 | nM | 7.27 |