Assay Detail
Binding
CHEMBL756255
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Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | SK-N-MC |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of neuropeptide Y Y1 receptor antagonists related to BIBP 3226.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.45 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44246 | — | — | 1 | 8.23 |
| CHEMBL288355 | — | — | 1 | 7.72 |
| CHEMBL41673 | — | — | 1 | 6.82 |
| CHEMBL41457 | — | — | 1 | 6.77 |
| CHEMBL41981 | — | — | 1 | 6.74 |
| CHEMBL42747 | — | — | 1 | 6.17 |
| CHEMBL42686 | — | — | 1 | 5.62 |
| CHEMBL41686 | — | — | 1 | 5.28 |
| CHEMBL290175 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44246 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL288355 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL41673 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL41457 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL41981 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL42747 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL42686 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL41686 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL290175 | — | IC50 | = | 22000.0 | nM | 4.66 |