Assay Detail
Binding
CHEMBL756367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for 50% Inhibition of activity against Protein Tyrosine Phosphatases 1B
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Divalent and trivalent alpha-ketocarboxylic acids as inhibitors of protein tyrosine phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.87 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129681 | — | — | 1 | 5.57 |
| CHEMBL338073 | — | — | 1 | 4.89 |
| CHEMBL341233 | — | — | 1 | 4.72 |
| CHEMBL128936 | — | — | 1 | 4.28 |
| CHEMBL129918 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129681 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL338073 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL341233 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL128936 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL129918 | — | IC50 | = | 250000.0 | nM | - |