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Assay Detail

CHEMBL756368

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory Activity against Recombinant Human PTP1
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.
Lazo JS, Aslan DC, Southwick EC, Cooley KA, Ducruet AP, Joo B, Vogt A, Wipf P.
J Med Chem (2001) 44 : 4042 -4049
PubMed 11708908 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.06 5.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL336095 1 5.10
CHEMBL57013 1 5.06
CHEMBL340653 1 5.01
CHEMBL340219 1 -
CHEMBL132324 1 -
CHEMBL339439 1 -
CHEMBL448099 1 -
CHEMBL337173 1 -
CHEMBL128320 1 -
CHEMBL128830 1 -
CHEMBL335110 1 -
CHEMBL310185 1 -
CHEMBL131657 1 -
CHEMBL334812 1 -
CHEMBL128764 1 -
CHEMBL131141 1 -
CHEMBL132160 1 -
CHEMBL337520 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL336095 IC50 = 8000.0 nM 5.10
CHEMBL57013 IC50 = 8700.0 nM 5.06
CHEMBL340653 IC50 = 9800.0 nM 5.01
CHEMBL340219 IC50 > 10000.0 nM -
CHEMBL132324 IC50 > 10000.0 nM -
CHEMBL339439 IC50 > 100000.0 nM -
CHEMBL448099 IC50 > 10000.0 nM -
CHEMBL337173 IC50 > 100000.0 nM -
CHEMBL128320 IC50 > 10000.0 nM -
CHEMBL128830 IC50 > 10000.0 nM -
CHEMBL335110 IC50 > 10000.0 nM -
CHEMBL310185 IC50 > 10000.0 nM -
CHEMBL131657 IC50 > 10000.0 nM -
CHEMBL334812 IC50 > 10000.0 nM -
CHEMBL128764 IC50 > 10000.0 nM -
CHEMBL131141 IC50 > 100000.0 nM -
CHEMBL132160 IC50 > 10000.0 nM -
CHEMBL337520 IC50 > 10000.0 nM -