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Assay Detail

CHEMBL756465

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested for the ability to inhibit the replication of HIV-1 strain HTLV IIIB in human peripheral blood mononuclear cells (PBMC)
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds.
Venkatachalam TK, Sudbeck EA, Mao C, Uckun FM.
Bioorg Med Chem Lett (2001) 11 : 523 -528
PubMed 11229762 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.46 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL148698 1 9.00
CHEMBL144604 1 8.15
CHEMBL146770 1 8.15
CHEMBL151773 1 8.05
CHEMBL929 DELAVIRDINE MESYLATE 4.0 1 8.05
CHEMBL116474 1 7.48
CHEMBL57 NEVIRAPINE 4.0 1 7.47
CHEMBL149100 1 7.16
CHEMBL145709 1 6.00
CHEMBL345783 1 5.05
CHEMBL151782 1 -
CHEMBL151850 1 -
CHEMBL345289 1 -
CHEMBL356247 1 -
CHEMBL345996 1 -
CHEMBL358280 1 -
CHEMBL149161 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL148698 IC50 = 1.0 nM 9.00
CHEMBL144604 IC50 = 7.0 nM 8.15
CHEMBL146770 IC50 = 7.0 nM 8.15
CHEMBL151773 IC50 = 9.0 nM 8.05
CHEMBL929 DELAVIRDINE MESYLATE IC50 = 9.0 nM 8.05
CHEMBL116474 IC50 = 33.0 nM 7.48
CHEMBL57 NEVIRAPINE IC50 = 34.0 nM 7.47
CHEMBL149100 IC50 = 70.0 nM 7.16
CHEMBL145709 IC50 = 1000.0 nM 6.00
CHEMBL345783 IC50 = 9000.0 nM 5.05
CHEMBL151782 IC50 > 100000.0 nM -
CHEMBL151850 IC50 > 100000.0 nM -
CHEMBL345289 IC50 < 1.0 nM -
CHEMBL356247 IC50 < 1.0 nM -
CHEMBL345996 IC50 < 1.0 nM -
CHEMBL358280 IC50 < 1.0 nM -
CHEMBL149161 IC50 < 1.0 nM -