Assay Detail
Binding
CHEMBL756522
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry, biochemistry, and pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.57 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1908349 | NALORPHINE HYDROCHLORIDE | -1.0 | 1 | 8.82 |
| CHEMBL2096625 | — | — | 1 | 8.52 |
| CHEMBL2310921 | — | — | 1 | 8.22 |
| CHEMBL3038189 | — | — | 1 | 8.22 |
| CHEMBL2310915 | — | — | 1 | 8.15 |
| CHEMBL3038190 | — | — | 1 | 8.15 |
| CHEMBL2310917 | — | — | 1 | 7.30 |
| CHEMBL2310916 | — | — | 1 | 7.05 |
| CHEMBL2310918 | — | — | 1 | 7.05 |
| CHEMBL2310922 | — | — | 1 | 7.00 |
| CHEMBL2310919 | — | — | 1 | 7.00 |
| CHEMBL2310920 | — | — | 1 | 6.89 |
| CHEMBL3038192 | — | — | 1 | 6.89 |
| CHEMBL3038191 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1908349 | NALORPHINE HYDROCHLORIDE | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2096625 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2310921 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3038189 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2310915 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3038190 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2310917 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2310916 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2310918 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2310922 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2310919 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2310920 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3038192 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3038191 | — | EC50 | = | 180.0 | nM | 6.75 |